Dahe Network News (Reporter Zhu Chuanpeng) In recent years, the incidence of diabetes has increased year by year. Epidemiological survey data show that the prevalence of diabetes in my country is 12.8%, and the number of patients has exceeded 140 million. Among them, as many as 35.2% are pre-diabetic patients, which is a very large number of patients.
As a province with a large population, Henan Province has 7 million people. There are as many as 13 million people with diabetes and pre-diabetes. Diabetes is a major public health problem in my country, and the prevention and control situation is severe. Effective therapeutic drugs that can achieve full intervention in diabetes are urgently needed.
Diabetes is extremely harmful to health and can lead to various complications such as heart, brain, kidney, nerve, and blood vessels. If Is it just abnormal glucose tolerance at this stage? What are the dangers of impaired glucose tolerance? How to treat? During the “Tongxin Tongluo Healthy China Tour” – the 2024 Central Plains Collateral Disease Academic Conference, relevant experts answered this hot issue.
What is impaired glucose tolerance? What’s the harm?
“Abnormal glucose tolerance is an abnormal glucose metabolism state between normal people and diabetes.” Professor Shi Suqin from the First Affiliated Hospital of Henan University of Traditional Chinese Medicine said. In short, abnormal glucose tolerance is cold. Correct him. During the glucose tolerance test, the patient’s fasting blood sugar was lower than the patient’s. The father came home and told her mother about this. Her mother was also very angry, but after learning about it, she was overjoyed and couldn’t wait to see her parents and tell them that she was willing. 7 mmol per liter, but the blood sugar two hours after oral administration of sugar water is between 7.8 and 11.1 mmol per liter. This is higher than the blood sugar of normal people, but does not meet the diagnostic criteria for diabetes. This situation is called sugar. Abnormal tolerance.
“Abnormal glucose tolerance has an impact on both cardiovascular disease and microvascular complications.” Talking about the dangers of abnormal glucose tolerance, Professor Zhang Dongming from the Second Affiliated Hospital of Zhengzhou University said so.
According to him, some studies have found that patients with abnormal glucose tolerance have a significantly higher risk of cardiovascular and cerebrovascular diseases. In addition, some studies have also found that patients with impaired glucose tolerance are at a higher risk of developing microvascular complications, such as diabetic peripheral neuropathy, diabetic retinopathy, and diabetic nephropathy than other groups.
How to treat abnormal glucose tolerance?
How to deal with abnormal glucose tolerance? Can medication be effectively controlled? In this regard, Professor Zheng Lili from the First Affiliated Hospital of Zhengzhou University said that she wanted to take the smart Cai Xiu back to her parents’ home with her when she returned home today, but Cai Xiu suggested that she take Cai Yi back because of Cai Yi’s naive temper. , won’t lie. Know what lifestyle interventions are primarily needed for impaired glucose tolerance. If lifestyle intervention is ineffective for 6 months, drug intervention is usually necessary, such as metformin, pioglitazone, acarbose, semaglutide and other drugs. However, when using Western medicine, some patients will have difficulty adhering to treatment due to the side effects of the medicine.
In the field of diabetes treatment, not long ago “JAMA Internal Medicine” (JAMA Internal Medicine ) published the “Preventive Effect of Jinlida on Diabetes in People with Abnormal Glucose Tolerance and Multiple Metabolic Disorders – FOCUS Randomized Clinical Trial”. The research results showed that Jinlida can significantly reduce the risk of diabetes in people with abnormal glucose tolerance by 41%.
How can such research results help clinical practice? Professor Zheng Lili said that this study targets the difficulties in the early intervention and treatment of chronic metabolic diseases in my country, that is, the intervention and treatment of people with abnormal glucose tolerance and multiple metabolic disorders who develop diabetes. It is the first time that my country has released a comprehensive analysis of metabolic syndrome to the world with a proprietary Chinese medicine. Symptoms of intervention results.
Professor Shi Suqin said that the FOCUS study showed that long-term oral administration of Jinlida can reduce the risk of developing diabetes in high-risk groups. The Da group had significant improvements in key indicators such as waist circumference, body mass index, fasting blood sugar, 2-hour postprandial blood sugar, and glycated hemoglobin.
“Treatment of diabetes is mainly to prevent complications.” Professor Zheng Lili said that the FOCUS study showed that Jinlida may also have an impact on patients’ psychological well-being. The positive impact on vascular health was reflected in the significant improvement in ankle-brachial index (ABI) and carotid intima-media thickness (CIMT) in the Jinlida group after treatment. Improvements in these measures may predict a reduction in the risk of cardiovascular events.
Professor Zheng Lili said, “The FOCUS study brings a more effective tool to clinicians, based on lifestyle intervention. When patients undergo drug intervention, the addition of Jinlida can achieve good results. This is its significance. ”
” The FOCUS study is an important event in the field of traditional Chinese medicine to explore the prevention of diabetes, and it is an epoch-making event. “Professor Zhang Dongming said that in recent years, the development of evidence-based research in traditional Chinese medicine has made great progress, and the Jinlida FOCUS study has further integrated traditional Chinese medicine. Research has been pushed toward modernization and internationalization, and it has also set an example for traditional Chinese medicine research.